3D-printed organs and body tissues made possible by controlled curing
Image credit: Dreamstime
3D printing could be used in the future to create artificial tissue to replace blood vessels and organs thanks to a new technique that allows for precise controls over an object’s firmness.
Engineers at University of Colorado Boulder have published details of how the layer-by-layer printing method can provide very fine programmable control over rigidity, allowing researchers to mimic the complex geometry of blood vessels that are highly structured and yet must remain pliable.
The findings could one day lead to better, more personalised treatments for people suffering from hypertension and other vascular diseases.
“The idea was to add independent mechanical properties to 3D structures that can mimic the body’s natural tissue,” said associate professor Xiaobo Yin, senior author of the study. “This technology allows us to create microstructures that can be customised for disease models.”
Hardened blood vessels are associated with cardiovascular disease, but engineering a solution for viable artery and tissue replacement has historically proved challenging.
To overcome these hurdles, the researchers found a unique way to take advantage of oxygen’s role in setting the final form of a 3D-printed structure.
“Oxygen is usually a bad thing in that it causes incomplete curing,” said postdoctoral researcher Yonghui Ding. “Here, we utilise a layer that allows a fixed rate of oxygen permeation.”
By keeping tight control over oxygen migration and its subsequent light exposure, Ding said, the researchers have the freedom to control which areas of an object are solidified to be harder or softer – all while keeping the overall geometry the same.
“This is a profound development and an encouraging first step toward our goal of creating structures that function like a healthy cell should function,” Ding said.
As a demonstration, the researchers printed three versions of a simple structure: a top beam supported by two rods. The structures were identical in shape, size and materials, but had been printed with three variations in rod rigidity: soft/soft, hard/soft and hard/hard. The harder rods supported the top beam while the softer rods allowed it to fully or partially collapse.
The researchers repeated the feat with a small Chinese warrior figure, printing it so that the outer layers remained hard while the interior remained soft, leaving the warrior with a tough exterior and a tender heart, so to speak.
The tabletop-sized printer is currently capable of working with biomaterials down to a size of 10 microns, or about one-tenth the width of a human hair. The researchers are optimistic that future studies will help improve the capabilities even further.
“The challenge is to create an even finer scale for the chemical reactions,” said Yin. “But we see tremendous opportunity ahead for this technology and the potential for artificial tissue fabrication.”
In August University of Minnesota researchers developed a technique that uses 3D printing to create bionic eyes that could one day help blind people see or sighted people see better.
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