Samsung is likely to have earned a quarterly profit of $8.1bn, as it sold close to 500 mobile handsets every minute.
That run of five straight record quarters may end in January-March on weak seasonal demand, though a strong pipeline of smartphones – the South Korean group's biggest earner – and improving chip prices have eased concerns that earnings growth could slow this year, powering Samsung shares to record levels.
"Guidance is unlikely to disappoint given new product launches and a further upturn in cyclical parts of the business," said Morgan Stanley analyst Shawn Kim. "Smartphone momentum has not decelerated, despite Apple's new iPhone, and the business continues to be driven by its flagship products.
"This time, it's the Galaxy Note II with the upside in unit shipments mainly from the US. We expect strong momentum to continue in the first quarter."
While Apple rolled out just a single new smartphone, the iPhone 5, last year globally, Samsung bombarded the market with 37 variants tweaked for regional and consumer tastes, from high-end smartphones to cheaper low-end models.
By comparison, Taiwan's HTC released 18 models, Nokia only nine, and LG Electronics released 24.
Samsung, valued at close to $230bn, gives its October-December earnings guidance later this week before the market opens.
The full earnings release is expected by 25 January.
Shipments of Samsung's flagship Galaxy S III, which overtook the iPhone 4S in the third quarter to become the world's best-selling smartphone, are likely to have slipped to around 15 million in the last quarter from 18 million in July-September.
But estimated sales of around eight million Galaxy Note II phone-cum-tablets, or 'phablets', should more than make up for that – pushing overall smartphone shipments to around 63 million, analysts estimate.
There has been increased speculation that Samsung will launch the next version of its Galaxy S in the first quarter, possibly with an unbreakable screen and full high-definition quality resolution boasting 440 pixels per inch, as well as a better camera and a more powerful processor.
"Samsung's smartphone shipments are likely to grow even in a seasonally weak first quarter.
The early launch of the Galaxy S IV would drive second-quarter growth momentum," said BNP Paribas Securities analyst Peter Yu, who predicts Samsung's 2013 operating profit will grow 25 per cent to almost $35bn.
Samsung is forecast to raise its smartphone sales by 35 per cent and widen its lead over Apple this year, driven by its diversified product line-up, said Neil Mawston, executive director at market researcher Strategy Analytics, which forecasts Samsung will sell 290 million smartphones this year, up from a projected 215 million in 2012.
Apple's smartphone sales are projected to reach 180 million this year, up by a third from last year's 135 million.
Samsung is likely to say this week that its October-December operating profit increased 65 per cent to 8.7 trillion won from a year ago, a Reuters survey of 16 analysts showed. That would be 7 per cent higher than its previous record of 8.1 trillion won in July-September.
Profits from the mobile division are seen slightly higher, at around 5.8 trillion won, than the previous quarter's 5.63 trillion won – and more than double last year's level.
A recovery in chip prices and flat screens may have also boosted its component earnings, propelled by booming sales of mobiles carrying Samsung's chips, micro-processors and flat screens.
Reflecting the upbeat outlook, shares in Samsung, Asia's most valuable technology stock, last week hit a life high of 1.584 million won ($1,500).
The stock gained 44 per cent in 2012, easily outpacing a 9 per cent rise on the broader Korean market and topping Apple's 31 per cent increase.
Samsung, LG Electronics and four Taiwan companies were last week fined millions of dollars for allegedly manipulating liquid crystal display panel prices in China in 2001-06, the state-run news agency Xinhua reported.